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(A) Secondary structure-based sequence alignment. (B) Structural superposition of SpAdK with AdKs from Bacillus subtilis (Bs), Escherichia coli (Ec); Aquifex aeolicus (Aa); Desulfovibrio gigas (Dg) and Homo sapiens (Hs). Conserved residues are labeled in black; arrows indicate the site-directed mutagenesis points.
