Table 2.

The distribution of natriuretic peptide receptors (NPRA, NPRB, and NPRC) and their gene-knockout phenotype.

Receptor	Ligand	Tissue-specific distribution	Cell-specific distribution	Gene-knockout phenotype
NPRA (Npr1)	ANP/BNP	Kidney, adrenal glands, brain, heart, liver, lung, olfactory, ovary, pituitary gland, placenta, testis, thymus, vascular beds, liver, ileum	Renal epithelial and mesangial cells, vascular smooth muscle cells, endothelial cells, Leydig cells, granulosa cells, fibroblasts, Neuroblastoma, LLCPk-1, MDCK cells	High blood pressure, hypertension, cardiac hypertrophy and fibrosis, inflammation, volume overload, reduced testosterone
NPRB (Npr2)	CNP	Adrenal glands, brain, cartilage, fibroblast, heart, lung, ovary, pituitary gland, placenta, testis, thymus, vascular beds	Vascular smooth muscle cells, fibroblasts, chondrocytes	Dwarfism, decreased adiposity, female sterility, seizures, vascular complication
NPRC (Npr3)	ANP, BNP, CNP	Kidney, heart, brain liver, vascular bed, intestine	Vascular smooth muscle cells, endothelial cells, mesangial cells, fibroblasts	Bone deformation, skeletal over-growth, long bone overgrowth
GC-D	Guanylyn/uroguanylyn	Olfactory neuroepithelium
GC-E/(ROS-GC-1)	Ca2+-binding proteins	Retina, pineal gland
GC-F/(ROS-GC-2)	Ca2+-binding proteins	Retina, rod outer segment
GC-G	Orphan	Skeletal muscle, lung, intestine, and kidney
GC-Y-X1	Orphan	Sensory neurons of C. elegans

NPRA, natriuretic peptide receptor-A; Npr1, coding for guanylyl cyclase/natriuretic peptide receptor-A; NPRB, natriuretic peptide receptor-B; Npr2, coding for guanylyl cyclase/natriuretic peptide receptor-B; NPRC, natriuretic peptide receptor-C; Npr3, coding for natriuretic peptide clearance receptor.