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Mechanism of healthy cell differentiation into ccRCC cell. Sample processes have been marked by: 1: lysosomal sequestration; 2: accumulation of BDMCs; 3: EMT; 4: angiogenic switch; 5: increased pericyte coverage; 6: reduced drug levels in serum/plasma. When these processes are activated - no matter if only one of them, or more parallely/subsequently, drug resistance and therefore metastasis will probably occur.
