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. 2014 Aug 16;63(9):3077–3090. doi: 10.2337/db14-0235

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© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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Diabetes does not affect the expression and phosphorylation of downstream targets of mTORC1. Rats with 3 months of diabetes were treated with either phloridzin twice daily or insulin subconjunctivally once daily for the last 4 days. Analysis of the levels of expression of 4E-BP1 and its phosphorylation on threonines 37 and 46 (A) and S6 ribosomal protein and its phosphorylation on serines 240/244 and serines 235/236 (B), downstream targets of TORC1, showed that neither was reduced by diabetes (n ≥ 5/group). C, control; D, diabetic; D+I, diabetic + insulin; D+P, diabetic + phloridzin; D+P+L, diabetic + phloridzin + local insulin.