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. Author manuscript; available in PMC: 2014 Aug 22.
Published in final edited form as: Immunol Allergy Clin North Am. 2010 Feb;30(1):75–101. doi: 10.1016/j.iac.2009.10.001

Figure 1. From discovery to validation of plasma biomarkers of acute graft versus host disease.

Figure 1

(This research was originally published in Blood. [115]

Panel A shows the heatmap of proteins levels measured sequential ELISA in the discovery set samples. Samples from 21 GVHD– patients (left) and 21 GVHD+ patients (right) are represented. Eleven proteins gave a P values for differences between GVHD+ and GVHD– patient plasma< 0.05. Panel B shows the receiver operating characteristic (ROC) curves of four individual discriminator proteins and the composite panel in the training set. Individual ROC curves for IL-2Ra,TNFR1, HGF, and IL-8 and the composite panel.