Figure 1.

Microarray micro-RNA profiling reveals differential expression of multiple micro-RNAs in brains of patients with multiple sclerosis. Microarray analysis of micro-RNAs extracted from tissues of patients with and without multiple sclerosis revealed differential expression of multiple micro-RNAs in multiple sclerosis brains. (A) The heatmap represents only those micro-RNAs whose expression was altered by at least 1.5-fold with both microarray and real-time reverse transcription–PCR analyses. Gene ontology term enrichment analysis of predicted targets of differentially expressed micro-RNAs showed targeting of different biological processes by multiple sclerosis-induced (B) or multiple sclerosis-suppressed (C) micro-RNAs.