Table 2.

Association of several novel risk markers with incident coronary heart disease (# events = 94)

	Univariable		Multivariable**
Marker	Hazard Ratio*(95% CI)	P value	Hazard Ratio*(95%CI)	P value
CAC	2.72(2.09 −3.55)	<0.0001	2.60(1.94- 3.50)	<0.0001
Brachial FMD	0.82(0.66 – 1.03)	0.09	0.93(0.74 – 1.16)	0.52
Carotid IMT	1.33(1.12-1.59)	0.001	1.17(0.95 -1.45)	0.13
ABI	0.78(0.66 – 0.93)	0.005	0.79(0.66 – 0.95)	0.01
hs-CRP	1.26(1.01 – 1.57)	0.045	1.28(1.00 – 1.64)	0.047
Family History	2.39(1.54 -3.70)	<0.001	2.18(1.38 – 3.42)	0.001

^*For continuous risk markers, HRs are standardized per unit standard deviation change in the marker.

^**Multivariable models adjusted for age, gender, race/ethnicity, systolic blood pressure, total cholesterol, HDL, smoking status, BMI, blood pressure medication use and HMG CoA reductase inhibitor use. CACcoronary calcium score, FMD- flow mediated dilation, IMT- intima-media thickness, ABI- ankle brachial index, hs-CRP- high sensitivity C - reactive protein. CAC and hs-CRP were log transformed.