Table 3.

Net Reclassification Improvement for Incident coronary Heart disease Events with Addition of novel risk markers to the Framingham Risk Score in MESA Participants with Intermediate Risk (n=1330).

Variable		Percent Reclassified	Low	Risk Category Intermediate	High	Net Correct Reclassification (%)	NRI
FRS	Events	-	-	94	-	-	-
	Non Events	-	-	1236	-	-
FRS + IMT	Events	7.4	0	87	7	7.4	0.102
	Non Events	5.3	50	1170	16	2.8
FRS + CAC	Events	51.1	12	46	36	25.5	0.659
	Non Events	54.9	589	557	90	40.4
FRS + FMD	Events	0.0	0	94	0	0.0	0.024
	Non Events	3.2	35	1196	5	2.4
FRS + ABI	Events	4.3	1	90	3	2.1	0.036
	Non Events	4	34	1186	16	1.5
FRS + CRP	Events	4.3	0	90	4	4.3	0.079
	Non Events	5.2	54	1172	10	3.6
FRS + FH	Events	8.5	0	86	8	8.5	0.160
	Non Events	11.2	116	1097	23	7.5

FRS – Framingham Risk Score, IMT – carotid intima- media thickness ,CAC – coronary calcium score, FMD- brachial flow mediated dilation, ABI – ankle brachial index, FH- Family history of coronary heart disease, CRP – high sensitivity c-reactive protein.