Table 4.

Net Reclassification Improvements for Incident cardiovascular disease Events with Addition of IMT,CAC, FMD, ABI, family history of CHD and Hs CRP over Framingham Risk Score in individuals with intermediate risk (n=1330) in MESA.

Variable		Percent Reclassified	Low	Risk Category Intermediate	High	Net Correct Reclassification (%)	NRI
FRS	Events	-	-	123	-	-	-
	Non Events		-	1207	-	-
FRS + IMT	Events	3.3	0	119	4	3.3	0.060
	Non Events	3.8	39	1161	7	2.7
FRS + CAC	Events	36.6	16	78	29	10.6	0.466
	Non Events	45.7	493	655	59	36.0
FRS + FMD	Events	2.4	3	120	0	-2.4	0.023
	Non Events	5.6	62	1140	5	4.7
FRS + ABI	Events	4.1	0	118	5	4.1	0.068
	Non Events	4.6	44	1151	12	2.7
FRS + CRP	Events	1.6	0	121	2	1.6	0.037
	Non Events	3.2	32	1168	7	2.1
FRS + FH	Events	2.4	1	120	2	0.8	0.040
	Non Events	4.9	49	1148	10	3.2

FRS – Framingham Risk Score, IMT – carotid intima- media thickness, CAC – coronary calcium score, FMD- brachial flow mediated dilation, ABI – ankle brachial index, FH- Family history of coronary heart disease, CRP – high sensitivity c-reactive protein.