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. 2014 Aug 22;6:214. doi: 10.3389/fnagi.2014.00214

Figure 6.

Figure 6

Brain region-specific effects of folate and mild MTHFR deficiencies on PP2A methylation and LCMT1 expression levels. 22-month-old wt mthfr+/+ and het mthfr+/− mice were fed for 6 months either a NF diet (Black bars, wt mice; gray bars, het mice) or a LF diet (hatched black bars, wt mice; hatched light gray bars, het mice). Relative methylated PP2Ac (A) and LCMT1 (B,C) protein expression levels were determined after quantitative Western blotting. Values represent mean ± SD for 9 mice per group; * p < 0.05, het vs. wt in the same diet group; # p < 0.05, LF vs. NF in the same genotype. Representative LCMT1 blots for two regions are shown in (B).