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The NIR-mediated cardioprotection is NOS-independent. The exposed heart of wild type and eNOS−/− mice was irradiated at 670 nm with 170 mW/cm2 power for 1 min during ischemia, and 4 min during reperfusion. Mice treated with L-NAME (10 mg/kg, administered 10 min prior occlusion) were also examined. Irradiation was equally protective in the case of control, L-NAME-treated, and eNOS−/− mice. Values are means ± SD, *p < 0.05 when compared to untreated control (CON).
