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. 2014 Aug 22;5:305. doi: 10.3389/fphys.2014.00305

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Copyright © 2014 Keszler, Brandal, Baumgardt, Ge, Pratt, Riess and Bienengraeber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NIR slows mitochondrial respiration in the presence of deoxymyoglobin and nitrite during reoxygenation. (A) Oxygen consumption of purified cardiac mitochondria was monitored with a Clarke-type oxygen electrode. At the beginning of ischemia, deoxyMb and sodium nitrite were added. During the second minute of ischemia before reoxygenation, mitochondria were exposed to NIR at 670 nm with 50 mW/cm² irradiance. (B) NIR caused an NO-dependent increase of reoxygenation rate (corresponding to a decrease of respiration) in the presence of deoxyMb and nitrite. The effect was reversed with NO scavenger CPTIO. Values are means ± SD, n = 6, ^*p < 0.05 when compared to control, ^#p < 0.05 when compared to NIR treated mitochondria in the absence of CPTIO.