. Author manuscript; available in PMC: 2014 Aug 22.

Published in final edited form as: Gene Ther. 2004 Apr;11(7):609–618. doi: 10.1038/sj.gt.3302194

Table 1.

TK enzyme activity in various cell lines that were double infected with Ad-CAG-loxP-PA-loxP-HSV1-tk and Ad-CMV-Cre demonstrating Cre-mediated conditional gene activation across various cell lines

	Cell lines tested
	C6	HeLa	LS 174T	N2a	293T
Single infection with Ad-CMV-HSV1-tk	0.29±0.03	0.12±0.01	0.02±0.01	0.12±0.00	0.26±0.12
Double infection with Ad-CAG-loxP-PA- loxP-HSV1-tk and Ad-CMV-Cre	4.56±0.24^a	0.75±0.04^a	0.12±0.00^a	3.67±0.45^a	3.35±0.26^a

Cells infected with Ad-CMV-HSV1-tk serve as positive controls. The values are mean±s.e.m.

Significantly higher (Student's t-test, P<0.05) than single virus infection.