Extended Data Table 1.

List of metabolites recognized by Metaboanalyst program and subsequently used for MSEA analysis.

Metabolites	HMDB ID
1-Acylglycerol	METPA0229
eicosatrienoic acid	HMDB02925
eicosadienoic acid	HMDB05060
eicosenoic acid	HMDB02231
Glycerophosphocholine	HMDB00086
LysoPC(18:0)	HMDB10384
LysoPC(18:2)	HMDB10386
LysoPC(18:3)	HMDB10387
LysoPC(22:0)	HMDB10398
LysoPC(22:6)	HMDB10404
LysoSM(d18:1)	HMDB06482
PA(34:1)	HMDB07858
hexadecenoic acid	HMDB03229
PC(36:1)	HMDB07887
PC(32:0)	HMDB00564
PC(36:2)	HMDB00593
PE(34:1)	MSEA0160
PE(34:2)	MSEA0161
PE(40:6)	MSEA0170
PhosphatidylgIyceroI	MSEA0606
glycerophosphoethanolamine	MSEA0611
phosphatidylserine	HMDB12330
PS(36:1)	HMDB10163
Sphingomyelin	HMDB01348
sphingosine	HMDB00252
Sphingosine 1-phosphate	HMDB00277