Table 4.
Incidence rates and HRs for ESRD associated with controlled and uncontrolled BP among REGARDS participants with treatment-resistant HTN
| No treatment-resistant HTN | Treatment-resistant HTN | ||
|---|---|---|---|
| Controlled BP | Uncontrolled BP | ||
| No. at risk | 7,827 | 564 | 1,583 |
| ESRD events | 42 (0.54) | 13 (2.30) | 97 (6.13) |
| ESRD incidence rate (95% CI) | 0.88 (0.65–1.19) | 3.89 (2.26–6.70) | 10.68 (8.75–13.04) |
| HR (95% CI) for ESRD | |||
| Crude | 1.00 (reference) | 4.42 (2.37–8.23) | 12.15 (8.46–17.45) |
| Age, race, sex-adjusted | 1.00 (reference) | 3.83 (2.05–7.15) | 9.94 (6.88–14.36) |
| Multivariable adjusted1 | 1.00 (reference) | 2.89 (1.52–5.47) | 7.68 (5.18–11.40) |
Note: ESRD events are given as number (percentage). Incidence rates are per 1,000 person-years.
ESRD: end-stage renal disease; BP: blood pressure; CI, confidence interval; REGARDS, Reasons for Geographic and Racial Differences in Stroke; HTN, hypertension; HR, hazard ratio
1
Adjusted for age, race, sex, region of residence, education, income, physical activity, current smoking, alcohol use, statin use, waist circumference, diabetes, total cholesterol, high-density lipoprotein cholesterol, C-reactive protein, history of myocardial infarction, and history of stroke.