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. Author manuscript; available in PMC: 2015 Jul 3.
Published in final edited form as: Cell. 2014 Jul 3;158(1):121–131. doi: 10.1016/j.cell.2014.04.044

Figure 2. Eukaryotic-specific features of the mRNA path visible from intersubunit space (A) and solvent side (B) of 40S subunit.

Figure 2

(A) Interaction of the P- and E-site tRNAs of the 80S POST complex (transparent gray) with mRNA. (B) Comparison of eukaryotic (transparent gray) and prokaryotic (red ribbon, Jenner et al., 2010, PDB ID 3I8G) mRNA paths. The model for the additional four nucleotides on the 3′-end of the eukaryotic mRNA is shown in cyan. Densities for the ligands were segmented from the cryo-EM map presented in Figure 1A. The models for tRNAs, mRNA and ribosomal proteins from the homology model of the human 80S ribosome presented in this paper. Ribosome orientations are indicated by orientation aids.

See also

Figure S2. Eukaryotic-specific contacts between P-tRNA and large ribosomal proteins.