Table 1. Patients' demographics and clinical characteristics.

	Controls, n = 19	Relapsing-Remitting MS (RR), n = 40		Progressive MS (Prog.), n = 41
	OIND, un-treateda	RRMS, treatedb	RRMS, un-treated	SPMS, un-treated	PPMS, un-treated
Gender [Female/Male]	19 [8/11]	19 [8/11]	21 [18/3]	20 [11/9]	21 [12/9]
Median age [Range]	57.0 [22–74]	44.0 [28–61]	37.0 [25–65]	58.0 [43–66]	53.0 [43–65]
Median EDSS [Range]	3.5 [0.0–7.0]c	1.5 [1.0–5.0]	1.5 [0.0–6.5]	6.5 [2.5–6.5]	6.0 [2.0–6.5]
Race	16 Cau/ 2 AA/ 1 A	18 Cau/ 1 A	14 Cau/ 5 AA/ 1 MR/ 1 Unkn	17 Cau/ 2 AA/ 1 MR	20 Cau/ 1 AA

^a Diagnoses: Cryptococcal meningitis (7), recurrent meningitis (1), systemic lupus erythematosus (1), cyclic fever (2), neuromyelitis optica (1), autoimmune lymphoproliferative syndrome-like disorder with CELs (1), persistently enhancing C-spine lesions (1), leukodystrophy-like disorder (1), CLIPPERS (Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids) (1), unclear diagnosis (3).

^b Long-term treatment with DAC HYP.

^c EDSS (Expanded Disability Status Scale) not available for each patient.

A: Asian, AA: African American, Cau: Caucasian, MR: Mixed race, Unkn: Unknown.