Table 3. Profile of family pedigree.

	Age(years)	Sex	Migraine onset and characteristics	Migraine type
II-3	68	F	Onset at time of first menstruation; simultaneously associated with limb pains	MO
II-5	59	M	No symptoms
III-2	45	F	Had experienced photophobia and phonophobia prior to onset of migraine attacks at the age of 13 years. Also experienced limb pains. Her migraine headaches were severer during menstruation.	MA
IV-3	12	F	Since childhood; simultaneously associated with limb pains	MO
IV-4	20	F	Since childhood; simultaneously associated with limb pains	MO

Four women with the GC gene mutation exhibited repeated episodes of transient, severe myalgia during childhood accompanied by migraines. However, one man with the GC gene mutation had never experienced myalgia or a migraine. F: female; M: male; MA: migraine with aura; MO: migraine without aura.