Figure 5. Pendrin gene ablation does not increase aortic contractile force through changes in Ca²⁺ sensitivity.

Rings from wild type and pendrin null mice were Ca²⁺ depleted by incubating in the presence of the Ca²⁺ chelator, EGTA, and then depolarized with 50 mM KCl. Vascular contractility was measured following the addition of calcium to the bath in increments of 0.2 mM [22], n = 5–6.