Figure 7. Inhibition of the angiotensin type 1 receptor equalizes aortic contractile force and cross sectional area in pendrin null and wild type mice.

Aortic rings from candesartan-treated wild type and pendrin null mice were isometrically mounted and maximum force generated/cross sectional area was measured in response to the cumulative addition of KCl (Panel A) and PE (Panel B) (n = 5–6). Cross sectional area of the aorta wall was measured in each of the vessels studied (Panel C). Aorta thickness (intima and media, Panel D) was measured by morphometry in separate candesartan-treated wild type (n = 6) and pendrin null (n = 6) mice. Body weights for the aorta thickness measurements were the following: wild type 24.4±0.9 g versus 21.4±1.0 g for pendrin null mice.