Figure 10. Angiotensin receptor type 1 inhibition eliminates the increase in MLC20 protein abundance observed in aortas from pendrin null mice.
Pendrin null and wild type mice were given candesartan for 14 days and then sacrificed. Contractile protein abundance (α actin and MLC 20) and a “housekeeping gene” (cdk4) were quantified by immunoblot in lysates of aortas taken from mice in each group. Representative immunoblots (Left Panel) and band density normalized to wild type mice (Right Panel) are shown.