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. Author manuscript; available in PMC: 2014 Aug 22.
Published in final edited form as: Clin Genitourin Cancer. 2012 Mar 14;10(2):69–76. doi: 10.1016/j.clgc.2012.01.002

Figure 2. The proposed stem-cell theory of cancer.

Figure 2

Figure 2

The proposed theory predicts that tumors arising from earlier stem cells in a stem-cell hierarchy tend to express a more diverse phenotype and pursue a more fulminant clinical course than do those that arise from later progenitor stem cells, which are more inclined to display a more restricted phenotype and follow a more indolent clinical course. Modified with permission from Springer.