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. 2014 Aug 22;9(8):e105828. doi: 10.1371/journal.pone.0105828

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© 2014 Ferreira et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Frequency of IgG subclass responders to the recombinant chimeric protein PvRMC-RBP1 and non-chimeric PvRBP1_23-751 among the IgG responders. The Chi squared test for proportions analyses was performed to determine that the frequency of IgG1 responders was significantly higher when compared with all others IgG subclasses. (B) The medians of reactivity indexes of IgG1 subclass against both antigens tested were also higher than IgG2, IgG3 and IgG4 by Mann Whitney test. * The frequency of IgG1 responders to PvRMC-RBP1 was significantly higher when compared with IgG2 (X² = 90.4; p = 0.0019), IgG3 (X² = 98.6; p<0.0001) and IgG4 (X² = 108.5; p<0.0001). # The frequency of IgG1 responders to PvRBP1_23-751 was significantly higher when compared with IgG2 (X² = 73.6; p<0.0001), IgG3 (X² = 54.6; p<0.0001) and IgG4 (X² = 55.9; p<0.0001). § The median of reactivity index of IgG1 to PvRMC-RBP1 was significantly higher than IgG2 (p<0.0001), IgG3 (p<0.0001) and IgG4 (p<0.0001) by Mann Whitney test. + The median of reactivity index of IgG1 to PvRBP1_23-751 was significantly higher than IgG2 (p<0.0001), IgG3 (p<0.0001) and IgG4 (p<0.0001) by Mann Whitney test.