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. 2014 Aug 22;9(8):e105896. doi: 10.1371/journal.pone.0105896

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© 2014 Budde et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The therapeutic impact of conventional extracorporeal photopheresis (ECP) on GvHD severity in the C57BL/6→BALB/c mouse model was assessed. Animals of the ECP group (---▪) were injected with 8-Methoxypsoralen and UV-A treated splenocytes from another cohort of C57BL/6→BALB/c transplanted GvHD animals with identical genetic chimerism. Animals received 3 ECP treatments in weekly intervals, started at day 1 after BMT. Control animals (—♦) received PBS injections at the same time points. Kaplan-Meier plot showing survival rates of the ECP treated vs. PBS control group (A). The ECP group consisted of 13 and the control group of 19 animals (*p<0.05, log rank test). Clinical GvHD score (B) and weight loss (C) were assessed daily.