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. 2014 Aug 22;9(8):e105891. doi: 10.1371/journal.pone.0105891

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© 2014 Ohara et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Influences of CYP2C9*3 mutation and body surface area (BSA) on CL(S) in the time courses of Cp(S) (A), VKORC1*2 and CYP4F2*3 on IC₅₀ in the time courses of NPT (B and C, respectively) and NPT₀ on λ in the relationship between NPT and INR (D) were predicted in typical Chinese patients with a BSA of 1.77 m² (165 cm and 70 kg) after administration of racemic warfarin at 3.0 mg/d.