Table 1. Inhibition of U251 Colony Formation by PCI-PTEN Protamine Sulfate (PS) or bPEI Polyplexes as Gene Carrier.
PTEN polyplexes concentration | PCI dark control | PCI 0.5 J/cm2 | PCI 0.75 J/cm2 |
---|---|---|---|
None | 100 ± 8.3a | 86 ± 6.7 | 72 ± 7.1 |
PS 1.0 mg/ml | 98 ± 7.1 | 27 ± 1.9b | 23 ± 1.8b |
PS 2.0 mg/ml | 91 ± 8.2 | 21 ± 1.8b | 16 ± 1.2b |
bPEI 1.0 mg/ml | 80 ± 6.3 | 45 ± 3.9b | 36 ± 2.6b |
bPEI 2.0 mg/ml | 63 ± 4.7b | 28 ± 1.9b | 18 ± 1.4b |
PS, protamine sulfate; bPEI, branched polyethylenimine.
Average value ± SE as a % of non-treated dark control.
Significant inhibition compared to control.