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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Hepatology. 2014 Jul 28;60(3):1090–1097. doi: 10.1002/hep.27088

Figure 2.

Figure 2

Proposed regulation of NTCP and MRP2 by PKC isoforms. Activation of aPKCζ and nPKCδ by cAMP leads to translocations of NTCP and MRP2 to PM. Activation of cPKC (most likely cPKCα) by PMA and TCDC induces retrieval of NTCP from PM, while activation of cPKCα by TUDC facilitates MRP2 translocation to PM. Activations of cPKCα, nPKC and nPKCε have been implicated in MRP2 retrieval from PM by estradiol 17β-D-glucuronide (E17G), ethacrynic acid (EA) induced oxidative stress and taurolithocholate (TLC), respectively. Retrieval of BSEP by E17G, PMA and oxidative stress has been proposed to be mediated via cPKCs (not shown).