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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Hepatology. 2014 Jul 28;60(3):1090–1097. doi: 10.1002/hep.27088

Figure 3.

Figure 3

Role of radixin and MARCKS in PM localization of MRP2. Phosphorylated radixin (active form) stabilizes MRP2 in the membrane by binding to actin and NHERF-1, which binds MRP2. MARCKS also binds actin and possibly MRP2 via an unknown protein X. Dephosphorylation of radixin (inactive form) by PP-1 activated by cPKCα/cPKCε and phosphorylation of MARCKS by nPKCε result in the loss of their binding to actin leading to retrieval from PM. Removal of radixin and MARCKS from PM results in the retrieval of MRP2 (dotted line), mostly likely due to the loss of PM anchoring proteins for MRP2. Similar mechanisms may also be involved in BSEP retrieval (not shown).