Table 1.
Effect of choleretic and cholestatic agents on PKC isoforms in rat hepatocytes.
| PKC isoforms |
Choleretic agents | Cholestatic agents | |||||||
|---|---|---|---|---|---|---|---|---|---|
| TC | TUDC | cAMP | GCDC | TCDC | TDC | TLC | E17G | EA | |
| cPKCα | ↑/− | ↑ | − | ↑ | ↑ | ↑ | ↓ | ↑ | − |
| nPKCδ | ↑/− | − | ↑ | ↑ | ↑ | ↑ | − | ND | ↑ |
| nPKCε | ↑/− | − | − | ↑ | ND | ND | ↑ | − | ↑ |
| aPKCζ | ND | − | ↑ | ND | ↑ | ND | − | ND | ND |
TC (15, 27, 83), TUDC (27, 83), GCDC(14), TCDC(83, 84), TDC (83) and TLC (19, 28, 45) have been shown to affect PKC isoform activity in hepatocytes. TC has been reported to activate (15, 83) cPKCα or to have no effect on cPKCα (27) in hepatocytes. E17G = Estradiol 17β-D-glucuronide (33), EA= ethacrynic acid (23), Activation (↑), inhibition (↓) or no effect (−); ND= not determined.