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Genetic consequences of somatic mtDNA mutations in the PolgA+/mut mouse colon. The ratio of non-synonymous mutations: synonymous mutations in PolgA+/mut mouse colonic crypts, the mtDNA mutator mouse germline and normal mouse strains. The ratio of non-synonymous to synonymous mutations is significantly higher in PolgA+/mut mouse colonic crypts compared to both the mtDNA mutator mouse germline and the normal mouse strains (p = <0.0001, Fisher's exact test).
