Figure 1.

Thermostability compensation in mammalian mitochondrial tRNAs. (a) The secondary structure of the human mt-tRNA^Trp with the known pathogenic mutations from Mitomap [68] shown in red. All instances when the disease mutation is found to be compensated in another species, as judged by a secondary structure-based alignment [69] are shown in orange. (b) An example of two direct WC compensations in the secondary structure of the Philippine tarsier mt-tRNA^Trp. (c) An example of an allosteric compensation in the anticodon stem of the sei whale mt-tRNA^Trp.