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. 2014 Aug 16;6:87. doi: 10.1186/1758-5996-6-87

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© Sala et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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General schematic representation of the mechanisms after RYGB that contribute for glycemic homeostasis and type 2 diabetes control. Legend: RYGB can control food intake through gastrointestinal hormones action. The reduced gastric pouch favors gastric emptying. In the liver, there is insulin sensitivity improvement, with decrease of insulin resistance and glucose output. In adipose tissue occurs decrease of inflammation and production oh proinflammatory cytokines, improving insulin sensitivity. In the pancreas the release of insulin increase and all these change leads to T2D remission. Abbreviations: GLP-1: Glucagon Like Peptide-1; PYY: Peptide YY; OXM: Oxyntomodulin.