Table 6.

Peak-values from the voxel-based morphometry controls > ALS patients.

Anatomical structure	Hemisphere	MNI coordinates (x,y,z)			Max. t-value	Corrected cluster p-value	Cluster size
Striatum	R	28	–10	12	5.52	< 0.001	460
(Putamen)	R	28	–2	–8	5.27
Thalamus	R	24	–28	14	4.63
(Pulvinar/ VLN)	R	16	–14	10	4.10
Pre-/ postcentral	L	–24	–18	30	5.38	< 0.001	521
Gyrus	L	–22	–28	48	5.08
	L	–10	–28	62	4.07
	L	–38	–10	38	3.96
Thalamus	L	–20	–18	10	5.26	< 0.001	404
(Pulvinar/ VLN)	L	–8	–14	–2	4.80
Striatum	L	–22	0	12	4.47
(Putamen)	L	–24	4	2	3.85
Precentral gyrus	R	18	–24	50	4.15	< 0.05	53
Hippocampus	L	–38	–26	–2	4.84	< 0.005	83
Hippocampus	R	34	–14	–20	4.15	< 0.05	58
OFC	L	–14	40	–14	4.95	< 0.01	81
OFC	R	20	44	–12	3.89	< 0.05	55
IFG	L	–36	10	28	5.86	< 0.001	131

Abbreviations: IFG, inferior frontal gyrus; OFC, orbitofrontal cortex; VLN, ventrolateral nucleus of the thalamus.