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. 2014 Sep 26;369(1652):20130503. doi: 10.1098/rstb.2013.0503

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© 2014 The Author(s) Published by the Royal Society. All rights reserved.

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Figure 1. — Quantification of brain-derived exosomes in the circulation of a patient with brain cancer. Following chromatographic isolation, circulating exosomes were quantified using a NanoSight NS300. The x-axis presents the size range of observed vesicles, the y-axis the concentration of vesicles and the z-axis the relative intensity. Panel (a) shows the circulating total exosome population, defined by the NS300 in light scatter mode. Panel (b) identifies those vesicles expressing a marker of brain-derived exosomes (β-amyloid), determined using the NS300 in fluorescent mode.