Figure 2.

Schematic of some main aspects of the roamer type of VT and of its possible implications for integrative actions in the CNS. It was shown inter alia that (i) exosomes can mediate oligodendrocyte–neuron communication [77]; (ii) exosomes can play a role in interconnections between brain and peripheral organs since, for example, cardiac myocytes release exosomes [84] and exosomes can cross the blood–brain barrier [85]; and (iii) exosomes can cause transient cell phenotype changes. Thus, it was shown that exosomes allow intercellular transfer of GPCRs [53].