Table 2.

EV composition in the CNS in health and disease.

cell type	health	disease
neurons	miRNA 124a, adhesion protein L1 Tsg101, Alix, GADPH, ubiquitin, HSP70, AMPA receptors, adapter protein Ndfip1	APP, APP metabolites and cleaving enzymes, prion proteins, aggregated proteins, including Aβ, α-synuclein, phosphorylated tau
oligodendrocytes	myelin proteins, HSP70, HSP90 and HSP71, metabolites, glycolytic enzymes, mRNA and miRNA	cholesterol
astrocytes	HSP70, EAAT, mitochondria, growth factors, angiogenic factors	HSP70, mutant SOD1, PARA4, ceramide, miRNA
microglia	late endosomal markers, MHC-class II, CD13	interleukins, co-stimulatory molecules IL-6, iNOS, COX-2