Vision Disorder (usually involving brief light trails, flashes or image persistence occurring at the edges of the visual field. Most commonly, these occur in association with light adaptation) |
62% |
Gastrointestinal Disorders
|
|
Nausea |
53% |
Diarrhea |
43% |
Vomiting |
40% |
Constipation |
27% |
Decreased Appetite |
19% |
Esophageal Disorders |
11% |
General Disorders
|
|
Edema |
28% |
Fatigue |
20% |
Other
|
|
Dizziness |
16% |
Neuropathy |
13% |
Dysgeusia |
12% |
Rash |
10% |
Investigations
|
|
Alanine Aminotransferase Increased |
13% |
|
Severe (grade 3 or 4) treatment related adverse events (all <1%-5% of cases)
|
|
Stomatitis |
Constipation |
Fatigue |
Dyspnea |
Neuropathy |
Pneumonitis |
Aspartate Aminotransferase Increased |
Alanine Aminotransferase Increased |
Neutropenia |
Lymphopenia |
Hypophosphatemia |
|
Additional recently described common and/or characteristic side effects
|
|
Renal cysts (rare) |
Asymptomatic bradycardia (frequency unknown) |
Rapid onset low testosterone in men (common) |