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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Biochem Pharmacol. 2014 Jul 18;91(2):249–255. doi: 10.1016/j.bcp.2014.07.007

Fig. 9. Overall metabolic pathways of PSA in vitro.

Fig. 9

PSA undergoes hydroxylation reactions at its butane-phosphate moiety to form mono-hydroxyl-PSA and di-hydroxyl-PSA, which are uniquely catalyzed by CYP3A4. PSA also can be oxidized and reduced at its sulindac moiety to form PSA sulfone and PSA sulfide, respectively.