Table 2.
Effect of the compounds on intracellular amastigotes of L. amazonensis and selectivity index.
| Samples | Macrophages CC50 (µg/mL) (95% C.I.)a |
Amastigotes CC50 (µg/mL) (95% C.I.)a |
Selectivity index (SI)b |
|---|---|---|---|
| Methanolic extract | 35.9 (±0.06) | 8.1 (5.8–11.2) | 4.4 |
| Hexane | 22.1 (±1.4) | 6.9 (4.0–11.8) | 3.2 |
aData are IC50 values in μg/mL and 95% confidence intervals are in brackets. bSelectivity index (SI) was calculated by dividing the CC50 of macrophages by the IC50 values of amastigotes of L. amazonensis.