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. Author manuscript; available in PMC: 2014 Aug 24.

Published in final edited form as: J Nucl Med. 2013 Aug 5;54(9):1535–1542. doi: 10.2967/jnumed.112.117952

Illustration of the different cases. Case 2 shows constraints and tumor BED for the case where the optimal dosing is not equal to the intersection of the MTD constraints. The 3^rd row (Case shows a case for a single limiting organ. 4^th row illustrates a case where all three organ constraints must be considered.

Illustration of the different cases. Case 2 shows constraints and tumor BED for the case where the optimal dosing is not equal to the intersection of the MTD constraints. The 3^rd row (Case shows a case for a single limiting organ. 4^th row illustrates a case where all three organ constraints must be considered.