Table 2A.
Mucinous vs. non-mucinous proteins identified in M-LAC bound fraction with relative abundance changes (spectral counts)
| Spectral Counts (Total peptides hits) | |||||||
|---|---|---|---|---|---|---|---|
| Analysis set 1 (fractions) | Analysis set 2 (fractions) | Pancreatic disease association b | |||||
| Protein namea | Gene nameb | Mucinousc | Non-mucinousc | Mucinousc | Non-mucinousc | Pancreatic cancer | Pancreatitis |
| Bile salt-activated lipase | CEL | 41 | 3 | 55 | 5 | yes(3.9) d | yes(18.2) |
| Carboxypeptidase A2 | CPA2 | 31 | 4 | 12 | 2 | yes(24.7) | yes(44.1) |
| Mucin-6 | MUC6 | 23 | 2 | 21 | 3 | yes(50.0) | yes(2.4) |
| Pancreatic triacylglycerol lipase | PNLIP | 21 | 3 | 13 | 2 | yes(1.0) | yes(49.0) |
| Pyruvate kinase isozymes M1/M2 | PKM | 14 | 2 | 12 | 1f | yes(22.3) | yes(6.3) |
| Periostin | POSTN | 3 | 20 | 4 | 23 | yes(35.2) | yes(11.6) |
|
| |||||||
| Alpha-amylase 2B | AMY2B | 43 | 4 | 46 | 2 | no | yes(22.9) |
| Calcium-activated chloride channel regulator 1 | CLCA1 | 78 | 3 | 23 | 1f | no | yes* |
| Carbonic anhydrase 1 | CA1 | 2 | ND | 16 | 2 | no | yes(17.3) |
| Pancreatic lipase-related protein 2 | PNLIPRP2 | 9 | 1f | 17 | 1f | no | yes(25.5) |
| Pancreatic alpha-amylase | AMY2A | 15 | 3 | 25 | 5 | no | yes(44.4) |
| Leucine-rich alpha-2-glycoprotein | LRG1 | 5 | 31 | 4 | 19 | no | yes(1.3) |
|
| |||||||
| Phosphoglycerate kinase 1 | PGK1 | 10 | 2 | 11 | 2 | no | no |
| Metalloproteinase inhibitor 1 | TIMP1 | 2 | 15 | 2 | 11 | no | no |
| Alpha-1-acid glycoprotein 2 | ORM2 | 37 | 5 | 21 | 3 | no | no |
| Interstitial collagenase | MMP1 | 36 | 6 | 42 | 3 | no | no |
| Fibronectin | FN1 | 63 | 2 | 77 | 2 | no | no |
| Tetranectin | CLEC3B | 2 | 19 | 2 | 14 | no | no |
| Vitamin D-binding protein | GC | 25 | 5 | 23 | 2 | no | no |
| Protein S100-A12 | S100A12 | 6 | ND | 2 | 11 | no | no |