Table 3.
Chromosome gene analysis of some ‘proteins of interest’
| Protein Name | Gene Name | Chromosome # | Cytogenetic band |
|---|---|---|---|
| Pancreatic alpha-amylase | AMY2A↑ | 1 | 1p21.1 |
| Alpha-amylase 2B | AMY2B↑ | 1 | 1p21.1 |
| Calcium-activated chloride channel regulator 1 | CLCA1↑ | 1 | 1p22.3 |
| Heat shock 70 kDa protein 6 | HSPA6 | 1 | 1q23.3 |
| Isoform 2 of Adenylyl cyclase-associated protein 1 | CAP1 | 1 | 1p34.2 |
| Chymotrypsin-like elastase family member 3B | CELA3B | 1 | 1p36.12 |
| Chymotrypsin-like elastase family member 3A | CELA3A | 1 | 1p36.12 |
| Pancreatic lipase-related protein 1 | PNLIPRP1↑ | 10 | 10q25.3 |
| Pancreatic triacylglycerol lipase | PNLIP↑ | 10 | 10q26.1 |
| Hexokinase-1 | HK1↑ | 10 | 10q22.1 |
| Catalase | CAT↑ | 11 | 11p13 |
| Mucin-2 | MUC2↑ | 11 | 11p15.5 |
| Mucin-6 | MUC6↑ | 11 | 11p15.5 |
| Cellular tumor antigen p53 | P53 | 17 | 17p 13.1 |
| Pigment epithelium-derived factor | SERPINF1↓ | 17 | 17p 13.3 |
| 14-3-3 protein epsilon | YWHAE↓ | 17 | 17p 13.3 |
| Puromycin-sensitive aminopeptidase | NPEPPS↓ | 17 | 17q21.32 |
a
protein names are from Swiss-Prot
b
Gene symbols, chromosome number, and cytogenic band are from Genecards
Green highlights = co-expressed genes observed in the pancreatic secretion pathway
Red highlights = co-located genes with oncogene p53 (yellow highlight)
Arrows denotes relative proteins expression levels in mucinous vs. non-mucinous fractions; ↑(higher levels in mucinous), ↓ (lower levels in mucinous)