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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Psychosom Med. 2014 Jan 16;76(2):101–108. doi: 10.1097/PSY.0000000000000029

Figure 1. Cognitive decline in participants with no copies and one or more copies of the APOE ε4 allele.

Figure 1

Cognitive decline in participants with no copies (A) and one or more copies (B) of the APOE ε4 allele for various levels of shortened Center for Epidemiologic Studies Depression scale are shown by each trend line. The lines are based on parameter estimates from a linear mixed model regression. The estimate of cognitive decline was 0.0412-unit per year (SE=0.0026) that increased by 0.0021-unit per year (SE=0.0008) for each additional symptom of depression among participants with no copies of the APOE ε4 allele (A). The estimate of cognitive decline was 0.0704-unit per year (SE=0.0046) that increased by 0.0051-unit per year (SE=0.0011) for each additional symptom of depression among participants with one or more copies of the APOE ε4 allele (B).