Figure 3.

Projections of the T4L structures onto the 2D essential subspace defined by the open-closed and twist modes. PCA was performed on the ensemble of 38 experimental structures of the T4L, and the first two eigenvectors with the largest eigenvalues defined the essential subspace. Each point on the plane represents a conformation. The 38 experimental structures of T4L are colored blue. The projections of MD (black) and ACM (red) indicate their sampling efficiency. To see this figure in color, go online.