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Effects of protease inhibitors on IL-6 and IL-17A gene expression and NF-κB activity in lung tissue. (a) Relative IL-6 and IL-17A mRNA expression in lung tissue. Results are expressed as means ± SDs for 6 mice/group. *P < 0.05 versus naïve group; # P < 0.05 between Der p-treated groups and (b) EMSA showed that all three serine protein inhibitors decreased NF-κB activation in lung tissue after Der p stimulation. The arrow indicates the specific DNA-probe complex.
