Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jul 26;4(10):960–971. doi: 10.7150/thno.9293

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

PMC Copyright notice

Effect of absorption on fluorescence in vivo. The effect of using homogeneous or heterogeneous absorption on the fluorescence reconstruction is analyzed 15 min after i.v. injection of a long circulating fluorescence-labeled nanocarrier designed for passive tumor accumulation. (A) 3D renderings of reconstructed fluorescence distribution. Left: Reconstruction using homogeneous absorption. Right: Reconstruction using heterogeneous absorption. Both reconstructions use the shape information. High signal is expected in well-perfused organs such as heart, liver and kidneys shortly after i.v. injection. (B) Transversal slice through the heart (arrow). Only when using heterogeneous absorption (right), the expected strong signal in the heart is reconstructed. (C) Slice through the liver. (D) Fluorescence after injection is significantly (P<0.01) lower in strongly absorbing organs such as heart and liver when assuming homogenous absorption.