Table 2.
Serum concentrations of estradiol, progesterone, luteinizing hormone (LH), thyroxine (T4), triiodothyronine (T3), and thyroid stimulating hormone (TSH) in female rats dosed with gossypol (25 mg/kg/day) or 0.9% saline (control group) subcutaneously for 15 consecutive days.
| Control (n = 12) | Gossypol (n = 12) | P value1 | |
|---|---|---|---|
| T4 (ng/dL) | 2.21 ± 0.10 | 1.80 ± 0.12 | 0.01446 |
| T3 (pg/mL) | 5.68 ± 0.41 | 7.73 ± 1.07 | n.s. |
| T3/T4 ratio | 2.62 ± 0.19 | 4.62 ± 0.77 | 0.02635 |
| TSH (µIU/mL) | 4.00 ± 1.76 | 3.91 ± 1.75 | n.s. |
| Progesterone (ng/mL) | 48.3 ± 7.61 | 24.5 ± 4.16 | 0.01317 |
| LH (mIU/mL) | 0.22 ± 0.04 | 0.21 ± 0.04 | n.s. |
| Estradiol (pg/mL) | 10.7 ± 3.83 | 16.7 ± 4.53 | n.s. |
1Welch's t test.
n.s.: not significant (P > 0.05).