Table 4.
Analgesic effect of KT floating beads (F10), KT solution and commercial KT tablets (Ketoral®) in mice using tail-flick method.
| Tested groups | Time of tail flick test (h) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.5 |
1.0 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
|
| Reaction time of analgesic effect in sec. (mean ± SE) | |||||||||
| Group І (Control) | 3.5 ± 0.13 | 3.2 ± 0.14 | 4.0 ± 0.25 | 3.7 ± 0.14 | 3.3 ± 0.11 | 3.5.±0.23 | 3.4 ± 0.14 | 3.3 ± 0.22 | 3.1 ± 0.18 |
| Group II (KT solution) | ⁎5.2 ± 0.19 | ⁎7.8 ± 0.20 | ⁎8.2 ± 0.31 | ⁎7.7 ± 0.28 | ⁎5.0 ± 0.20 | 3.7 ± 0.29 | 3.2 ± 0.22 | 3.4 ± 0.18 | 3.5 ± 0.11 |
| Group III (Ketoral®) | ⁎4.1 ± 0.20 | ⁎5.5 ± 0.21 | ⁎7.3 ± 0.11 | ⁎8.4 ± 0.14 | ⁎6.6 ± 0.13 | ⁎6.3 ± 0.12 | ⁎4.6 ± 0.15 | 3.2 ± 0.15 | 3.0 ± 0.21 |
| Group ІV (F10 fast) | ⁎4.3 ± 0.10 | ⁎4.6 ± 0.13 | ⁎5.7 ± 0.16 | ⁎6.3 ± 0.13 | ⁎7.5 ± 0.15 | ⁎7.3 ± 0.14 | ⁎5.1 ± 0.14 | ⁎4.5 ± 0.16 | 4.1 ± 0.13 |
| Group V (F10 fed) | ⁎4.4 ± 0.22 | ⁎4.2 ± 0.19 | ⁎6.4 ± 0.15 | ⁎7.5 ± 0.28 | ⁎7.9 ± 0.10 | ⁎7.9 ± 0.26 | ⁎7.5 ± 0.22 | ⁎7.5 ± 0.12 | ⁎7.0 ± 0.18 |
All values are means ± SE of six determinations.
⁎
Indicates that a significant increase in the analgesic effect was obtained (p < 0.05) as compared to a control.