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Increased cardiac inflammatory cytokines following LPS administration in APN-KO mice. (a) Myocardium TNF-α levels in WT (n = 5) and APN-KO (n = 5) mice 6 h after LPS or vehicle injection. (b) Myocardium IL-6 levels in WT (n = 5) and APN-KO (n = 5) mice 6 h after LPS or vehicle injection. Levels of mRNA in the myocardium of WT and APN-KO mice were quantified by real-time RT-PCR and expressed relative to GAPDH mRNA levels. Results are presented as mean ± SE.
