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. 2014 Jun 7;3(6):642–651. doi: 10.1016/j.molmet.2014.05.007

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

PMC Copyright notice

Phd3 interference promotes HIF-1, fibrosis and inflammation in WT AT. 12-week-old female C57/Bl6 mice (n = 7) were injected with Phd3 interference adenovirus (shPHD3) in one inguinal fat pad and a control vector (shNS) in the contra-lateral pad. qPCR quantification of (A) Phd3 and Erα, (B) Lox, Col1α1 and Col3α1 Col6α1 and (C) TNFα, IL6 and IL1β and TLR4 mRNA in inguinal ATs. Data shown as mean ± s.e.m. *P < 0.05 by two-tailed Student's t-test relative to shNS. See also Supplementary Figures 3 and 4.